Fast dissolving films have been played an important role in the current pharmaceutical research. They have convenience and ease of use over other dosage forms such as orally disintegrating tablets and immediate release tablets. In the present research, rapidly dissolving films of flunarizine dihydrochloride were developed using low viscosity grades of HPMCE50LV, CMC as film forming polymers. HPMCE50LV, CMC is a water soluble synthetic polymer which was used as film former. The films of flunarizine dihydrochloride were prepared by solvent casting method using ethanol as solvents. The prepared films were evaluated for drug content, weight variation, thickness, pH and in-vitro disintegration time. Flunarizine dihydrochloride is a hypertensive drug; taste masking was achieved by use of sweeteners, flavors’ and sodium saccharin. The in-vitro dissolution time of the optimized formulation was carried 30, 60, 90, 120, 150, 180 sec respectively. The prepared films exhibited good integrity and thickness. In-vitro dissolution studies were performed as per the FDA dissolution guidelines for about 3 minutes, the optimum formulation released complete drug within 2.5 minutes. Dissolution was done for all prepared formulation among all formulation F -7 formulations which are having HPMC E 50 LV and SLS in-vitro drug release 98.6 % in 3 seconds FTIR studies showed no drug polymer interaction.
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